Benefits Trend of Chinese Medicine Powder Tablet Press Machine
Three elements of the operation process of traditional Chinese medicine powder tablet press: good fluidity: make the powder operations such as flow and filling go smoothly, and reduce the difference in tablet weight; good compression formability: no bad phenomena such as cracks; good lubricity: tablet The tablet is non-sticky, resulting in a complete, smooth tablet. Most drugs need to be granulated before tableting. On the one hand, it is to meet the needs of the process, that is, to improve the fluidity and filling performance of the material to ensure the uniformity of the dosage. On the other hand, it can greatly improve the compression formability, that is, the adhesive is evenly distributed on the surface of the particles to change the bonding force between the particles and change the viscoelasticity of the material. In addition, an appropriate amount of water in the material is conducive to forming; glidants added to the prescription, such as micro-powder silica gel, can improve the compressibility; lubricants, such as magnesium stearate, although reducing the strength of the tablet, can also reduce the tablet strength. lobes. Simplifying the process is one of the important measures of GMP standardized management. Although the process of powder direct compression is simple, the application of this process is limited due to the fact that powder compression is easy to crack, and the powder has poor fluidity and serious tablet weight differences. However, in recent years, with the development of new functional excipients and The application of modern pharma machinery makes powder direct compression become one of the hotspots in pharmaceutical research. Traditional Chinese medicine tablet refers to the medicine fine powder or extract mixed with suitable excipients, processed and compressed into round or other tablet-shaped dosage forms for internal and external use. The research and production of Chinese medicine tablets only started in the 1950s. With the comprehensive research of Chinese medicine chemistry, pharmacology, preparation and clinical aspects, the variety and quantity of Chinese medicine tablets continued to increase, the technology was improved day by day, and the quality of the tablets gradually increased. improve. In addition to general compressed tablets and sugar-coated tablets, traditional Chinese medicine tablets also include microcapsule tablets, buccal tablets, tablets for external use, and effervescent tablets. In terms of tablet production technology, a set of process conditions suitable for the production of traditional Chinese medicine tablets has been gradually explored, such as the preparation of tablets containing fatty oil and volatile oil, how to improve the hardness of traditional Chinese medicine tablets, improve disintegration, and tablet coating And so gradually accumulate experience, so that the quality continues to improve. In addition, research on the dissolution rate and bioavailability of drugs in traditional Chinese medicine tablets has been gradually carried out. In short, tablets have become one of the dosage forms with many varieties, large output, wide application, convenient use, storage and transportation, and stable quality. Tablets account for more than 1/3 of the preparations recorded in the pharmacopoeias of China and many other countries. , it can be seen that the application is wide. The advantages of compressing traditional Chinese medicine into tablets are as follows: generally, the dissolution rate and bioavailability of tablets are better than those of pills; the dosage is accurate, and the difference in drug content in tablets is small; the quality is stable, and tablets are dry solids. Some drugs that are prone to oxidative deterioration and deliquescence can be protected by coating, so light, air, moisture, etc. have little impact on them; it is more convenient to organize, carry, transport, and take; mechanized production, large output, low cost,“Hygienic standards' are also easy to achieve. The above is the industry sharing brought to you by Lvyi high-speed tablet press machine, I hope you can like it. More about rotary tablet press machine, candy tablet press machine, soft water salt tablet press machine, powder tablet press machine, effervescent tablet press machine, chicken bouillon block tablet press machine, health product tablet press machine, please pay attention to us at any time Master the latest trends in the industry!
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