Design and construction of tertiary biosafety laboratory
Design and construction of tertiary biosafety laboratory
The whole level 3 biosafety laboratory is completely sealed, and the room is under negative pressure, so that the gas inside the laboratory will not escape to the outside and cause pollution; the laboratory must be installed with a biological safety cabinet of level II or above; all Operations involving infectious materials should be performed in biosafety...
Text Label: Level 3 Biosafety , Design and Build
Design and construction of three-level biosafety laboratory
The whole level 3 biosafety laboratory is completely sealed, and the room is under negative pressure, so that the gas inside the laboratory will not escape to the outside and cause pollution; the laboratory must be installed with a biological safety cabinet of level II or above; all Operations involving infectious materials should be carried out in biological safety cabinets. When such operations have to be carried out outside biological safety cabinets, comprehensive protective measures of personal protection and the use of physical restraint equipment must be adopted; before staff enter the laboratory work area , You should wear back-opening overalls or other protective clothing in a dedicated dressing room or buffer room. You must take off your overalls after work. You must not leave the laboratory in your overalls. Reusable overalls must be disinfected and then cleaned. Gloves must be worn when working. , Disposable gloves must be sterilized and then discarded.
The third-level biosafety protection laboratory can be set up in a building with other purpose buildings, but it must form its own area, which is separated from the public corridor or public parts by the isolation door; the laboratory should clearly distinguish the work area and protection area, it should be a self-contained area in the building or an independent building, and there should be access control; the laboratory auxiliary work area suitable for non-airborne biological agents should include at least a monitoring room and a clean clothes changing room. The area should include at least a buffer room and a core work room; the work room directly engaged in high-risk operations in the protection area is the core work room, and personnel should enter the core work room through the buffer room; If necessary, a transfer window with air supply and exhaust or self-purification function should be set up, and the exhaust air should be filtered and discharged through a HEPA filter. All gaps and penetrations of the enclosure structure in the laboratory protection area should be reliably sealed; the corners between ceilings, floors and walls should be easy to clean, sterilize and sterilize; the ground should be leak-proof, complete, smooth, non-slip, and durable. Corrosion and no dust; all windows should be closed windows, and the glass should be resistant to impact and breakage; the height of the equipment room should meet the installation requirements of the equipment, and there should be space for maintenance and cleaning; when the ventilation and air conditioning system is in normal operation, smoke should be used. When checking the tightness of the containment structure within the laboratory protection zone by visual means such as testing, there should be no visible leakage from all gaps. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for biosafety laboratories and GMP laboratories.
Three-level biosafety pharma machinery ventilation and air conditioning system: an independent air supply and exhaust system should be installed to ensure that the airflow flows from low-risk areas to high-risk areas during laboratory operation, and to ensure that pharma machinery air can only be filtered by HEPA After being filtered by the filter, it is discharged through a special exhaust duct; the air discharged from the laboratory protection area shall not be recycled; the position of the air supply and exhaust outlets in the room of the protection area should conform to the principle of directional airflow, which is conducive to reducing the eddy current and airflow in the room. The supply and exhaust air should not affect the normal function of other equipment; the supply air should be filtered by HEPA filter, and both primary and medium-efficiency filters should be installed at the same time; the external air outlet should be set in the downwind direction of the dominant air, and in a straight line with the air supply outlet The distance should not be greater than 12m, and should be at least 2m above the top of the building where the laboratory is located. It should be designed to prevent wind, rain, rodents, and insects, but it should not affect the gas discharge to the air; the installation position of the HEPA filter should be as far as possible. Close to the air supply port end of the air supply duct in the laboratory and the exhaust port end of the exhaust duct in the laboratory; Bio-type airtight valves should be installed at the key nodes of the air supply and exhaust ducts in the laboratory protection area, if necessary. Completely closed, bio-type airtight valves should be installed at the key nodes of the laboratory air supply and exhaust air pipeline, and can be completely closed if necessary; there should be a spare exhaust fan, and the length of the positive pressure section of the exhaust duct behind the exhaust fan should be minimized , the pipe should not pass through other rooms.
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