Design and installation of clean laboratory system
Design and installation of clean pharma machinery system
The clean laboratory air supply has at least three stages of filtration, initial, medium and high efficiency, and the high-efficiency filter should be set at the end of the system. The air filter is the most important equipment in the air cleaning system. There are three types of filters. Class: primary filter, medium efficiency filter, high efficiency filter...
Text label: clean laboratory system, laboratory design and installation
Clean laboratory system design and installation
The clean laboratory air supply has at least three stages of filtration, initial, medium and high efficiency, and the high-efficiency filter should be set at the end of the system. The air filter is the most important equipment in the air cleaning system. There are three types of filters. Class: primary filter, medium-efficiency filter, high-efficiency filter or sub-high-efficiency filter; primary-efficiency filter is mainly to block settled dust particles and various foreign bodies with a particle size of more than 10 microns; medium-efficiency air filter first Filter out dust of 1-10 microns; high-efficiency filters are mainly used to capture particulate dust and various suspended solids below 0.5 μm, as the end filter of various filtration systems, using ultra-fine glass fiber as filter material, offset paper, The aluminum foil board and other materials are folded as a separator, sealed with a new type of polyurethane sealant, and made of galvanized sheet, stainless steel sheet, and aluminum alloy profile as the outer frame. The clean laboratory should have sufficient air supply for purification and air conditioning; the necessary pressure gradient, positive pressure gradient or negative pressure gradient should be maintained; there should be a reasonable airflow organization.
The laboratory must maintain a certain temperature and airflow, and the experimental area should maintain a negative pressure relative to the corridor and non-experimental area; in the design of the laboratory, not only the flow direction of the airflow, but also the flow rate, different cleanliness levels or different functions should be considered The pressure difference in the room is usually 5-10Pa, and the pressure difference between different functional rooms adjacent to the biosafety laboratory is usually 10-15Pa. The route of personnel and logistics should be fully considered to minimize the backflow and eddy current of indoor air to avoid pollution. If there are no special requirements, the temperature should be 18-26℃ and the relative humidity should be 45-65%; The static pressure difference between non-clean rooms should be greater than 10pa, the pressure difference between adjacent clean rooms with different cleanliness levels should be greater than 5pa, and the pressure difference between clean area and outdoor should be greater than 12pa; The measured air volume and the number of air changes should be greater than the respective design air volume or air change number, but should not exceed 20%, and the difference between the air volume of each indoor air outlet and the design air volume of each air outlet should not exceed ±15% of the design air volume; one-way flow The average wind speed measured in the clean room should be greater than the design wind speed, but should not exceed 15%; the illumination in the clean area without lighting is 200Ix-500Ix, and the auxiliary room, personnel purification and material purification room, airlock room, corridor, etc. should be 150Ix -300
Ix, GMP regulations are not less than 300Ix; the noise of non-unidirectional flow clean room should not be greater than 60dB(A) in the empty state of clean room, and the noise of unidirectional flow and mixed flow clean room should not be greater than 65dB(A) ; Generally, the self-cleaning time of a one-way flow clean room is better within 10 minutes, and the self-cleaning time of a non-one-way flow clean room should be no more than 30 minutes. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean laboratories and sterile laboratories.
In order to prevent the pressure difference from reversing in the clean laboratory, the blower can only be turned on after the exhaust air of the biosafety clean room is turned on, and the exhaust fan can only be turned off after the blower is stopped first. Air supply fans; independent air supply and exhaust systems should be used to prevent cross-infection of aerosols; negative pressure clean benches should be used for reagent preparation, specimen processing, and experimental devices in the parts that generate harmful gases; the setting of air-conditioning room directly affects the project cost and noise. Therefore, the layout of the computer room should be considered uniformly in the design stage of the plane plan. It is best to purify the air-conditioning computer room close to the clean room that requires air supply, and strive to keep the air duct line short, but it is also required to prevent noise and vibration. Separation from the clean room, both aspects should be considered.
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