Filling and sealing in dust-free workshop
Filling and sealing in dust-free pharmaceutical cleanroom
Clean room ampoule filling and sealing includes filling equipment, filling and sealing equipment, and sealing equipment. Generally, the filling and sealing are connected together. The process of filling and sealing ampoules generally includes processes such as bottle loading of ampoules, filling of material liquid, nitrogen filling and sealing.
Text label: filling and sealing in clean workshop, filling design and installation in clean pharmaceutical cleanroom
Filling and sealing in dust-free pharmaceutical cleanroom
Clean room ampoule filling and sealing includes filling equipment, filling and sealing equipment, and sealing equipment. Generally, the filling and sealing are connected together. The process of filling and sealing ampoules generally includes processes such as bottle loading of ampoules, filling of material liquid, nitrogen filling and sealing. Within a certain time interval, the quantitative ampoules are discharged to the conveying device of the filling and sealing machine at certain distance intervals, and then sent to the next process through the conveying device for filling and sealing of the ampoules; the filling of the material liquid will be sterile filtered. The liquid is injected into the ampoules according to the corresponding filling requirements according to a certain volume. The perfusion of the material liquid is mainly realized by the perfusion metering mechanism. According to the dynamic principle of the metering mechanism, it can be divided into piston type and peristaltic pump.
The sealing of ampoules is accomplished by flame heating. The ampoules that have been filled with the material liquid and filled with nitrogen enter the preheating zone of the ampoules through the conveying part. In the preheating zone, the ampoules rotate through bearings to ensure that the neck is heated. Uniformity, after being heated evenly, it enters the sealing area. In the sealing area, the ampoule is melted at high temperature. At the same time, under the action of rotation, the excess part of the upper part of the ampoule is pulled away by mechanical action with a wire drawing pliers. The ampoule is tightly sealed, and the neck presents a smooth spherical shape due to the centrifugal force and surface tension. The sealed ampoule is tight and leak-proof, with uniform thickness. Through the analysis of the ampoule sealing process, it can be seen that the ampoule filling and sealing machine can be mainly divided into three basic parts: the transmission part, the pouring part and the sealing part according to its functional structure. The transfer part realizes the transfer of ampoules, and the statistics of the number of ampoules input and the number of ampoules filling and sealing can be realized through electromechanical control; the filling part pays attention to inject a certain volume of material into the sterilized ampoules, and can automatically stop filling according to the number of ampoules input. , to prevent waste of material and liquid; the sealing part mainly realizes the sealing of ampoules after material and liquid infusion, and the sealing has been uniformly sealed by wire drawing. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for dust-free workshops and sterile workshops.
Ampoule wire drawing and filling machine is a kind of equipment with compact structure and many cross-bar spaces. Each part is controlled by the main shaft driven by the motor; The ampoules after bacteria are put into the hopper through the stainless steel plate. The plum blossom plate under the hopper is driven by the chain. With the rotation, two ampoules can be pushed into the fixed tooth plate. The fixed tooth plate is composed of two upper and lower triangular teeth. The position of the triangle on the tooth plate is exactly corresponding, the upper and lower ends of the ampoule are just fixed in its triangular groove, and the ampoule forms an angle of 45° with the horizontal. When the eccentric shaft makes a circular motion, it drives the bottle-moving tooth plate connected to it. When the bottle-moving tooth plate that moves in a circular motion with the eccentric shaft moves to the upper half, the ampoule is now lifted from the fixed tooth plate. The sealing part is mainly composed of three parts: wire drawing mechanism, heating mechanism and bottle pressing mechanism; in the wire drawing device, there is a guide rail on the pliers seat, and the wire drawing pliers can slide up and down along the guide rail. With the help of the cam and the air valve, the compressed air can be controlled to enter the wire drawing pliers pipeline , and then the opening and closing of the jaws can be controlled. The main component of the heating device is the gas nozzle; when the ampoule is sent to the sealing station by the bottle transfer tooth plate, its neck rests on the tooth groove of the fixed tooth plate, and the lower part is placed on the worm gear. On the roller of the worm box, the bottom is placed on the hemispherical support head, and the upper part is pressed by the bottle pressing roller; after the ampoule is sealed, the bottle pressing cam and the swing rod release the bottle pressing roller, and the bottle shifting tooth plate presses the ampoule. Send out; high efficiency and strong automation.
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