Filling and sealing in GMP workshop
Filling and sealing in GMP pharmaceutical cleanroom
Decompression filling varies with the type of eye drop bottle and the size of the production volume. The intermittent pressure reduction filling device arranges the cleaned and sterilized empty eye drop bottles upside down in a flat tray, and put them in In the vacuum filler, the droplets are quantitatively put into the tray from the liquid storage bottle by the pipeline, and the door of the filler is closed...
Text label: GMP pharmaceutical cleanroom, filling and sealing, Zhongjing Global Purification
GMP pharmaceutical cleanroom plant filling and sealing
Decompression filling varies with the type of eye drop bottle and the size of the production volume. The intermittent pressure reduction filling device arranges the cleaned and sterilized empty eye drop bottles upside down in a flat tray, and put them in In the vacuum filling device, the droplets are quantitatively put into the tray from the liquid storage bottle by the pipeline, the door of the filling device is closed, and the pressure is reduced by the vacuum pump. The bottle device is filled with air, restored to normal pressure, poured into the bottle, taken out of the plate, immediately sealed and tightened the cover; a pressure cooker can be used to make a pressure-reduced filling device for small-scale production. Manual filling is suitable for small-scale production in the hospital preparation room. The filling device is mainly composed of two single-stage pistons in series.
A small amount of eye drops is prepared in the preparation room, the prepared eye drops can be put into the infusion bottle, the cap is sterilized, a disposable infusion filter is installed, and an interceptor and a terminal filter are put on; the device is cheap The filtration effect is reliable. The particle count of the filtrate filtered by the terminal filter is much lower than that of the filtrate filtered by the vertical melting glass funnel. This infusion set is one-time use, saving the process of processing various filters. powerful. The fully automatic filling unit integrates machinery, electronics and pneumatics. The production line consists of automatic bottle unscrambler, drum bottle washing machine, ozone sterilization oven, buffer bottle supply disc, filling machine, light inspection machine, It is composed of vertical labeling machine, which has the functions of bottle filling, no bottle filling, inner stopper on the bottle, and outer cover of the bottle with inner stopper. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and purification plants.
The plastic eye drop bottle that needs to be sealed in the GMP workshop can be sealed by hot-melt method, and the eye drop bottle is separated by cellophane. The temperature is about 90-100℃ during ironing, and it can be melted with a little pressure; corneal trauma and Eye drops packaged in ampoules for eye surgery can be filled by hand, sealed by hand, or mechanically sealed; there are top seals and pull seals. , according to the number of flames, it is divided into single flame and double flame, the latter is fast and easy to operate.
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