GMP clean workshop tablet equipment
GMP clean workshop tablet equipment
The production methods of tablets in GMP clean workshops include direct compression method and granule compression method. In the direct compression method, after mixing the drug with appropriate excipients, it is directly placed in a tableting machine without preparing granules for tableting. Method, the granule tableting method is to make raw and auxiliary powder powder into granules, and then place them in a tablet press...
Text label: GMP clean workshop, clean pharmaceutical cleanroom equipment, tablet equipment
GMP clean workshop tablet equipment
The production methods of tablets in GMP clean workshops include direct compression method and granule compression method. In the direct compression method, after mixing the drug with appropriate excipients, it is directly placed in a tableting machine without preparing granules for tableting. Method, granule compression method is to make raw and auxiliary material powder into granules, and then place it in a tablet machine to compress. The purpose of granulation in tablet production is mainly to increase fluidity and compressibility. The granulation methods are divided into wet granulation, dry granulation and boiling drying granulation. Commonly used granulation equipment includes rocking granulator. , high-efficiency mixing granulator and boiling drying granulator, etc. Wet granulation is to add a binder or wetting agent to the powder, and make the powder aggregated by the bridging or bonding of the liquid to prepare granules. It has the advantages of beautiful appearance, strong wear resistance, and good compression formability. More widely, commonly used equipment are rocking granulator, high-speed mixing granulator and so on.
The factors that affect the quality of granulated products in the high-speed mixing granulator are: the influence of the rotating speed of the stirring paddle and the cutting knife. When the rotating speed of the cutting knife is slow, the particle size becomes larger; When the rotating speed of the stirring paddle is slow, the particle size is small, and when the rotating speed is increased, the particle size is large, and the two have opposite effects; the slurry concentration of the material affects the slurry concentration of the material. When producing smaller particles, the slurry concentration of the material can be a little thinner. , when larger particles need to be produced, the slurry concentration of the material can be slightly thicker. The high-speed mixing granulator relies on a high-speed rotating agitator to quickly complete dry mixing, wet mixing, and granulation operations. It generally takes 8-10 minutes to prepare a batch of granules. It is easy to operate and has no accumulation and scaling. The high-speed motor can meet different granulation requirements; the granulation operation is in a fully closed state, and the produced granules are approximately spherical, with good fluidity and automatic unloading. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and clean workshops.
The boiling granulator integrates mixing, granulation and drying. It can be used for granulation of tablets, granules and capsules, as well as drying of powdery and granular wet materials. High production efficiency and uniform content of finished particles. The material powder particles are in an annular fluidized state in the raw material container. They are preheated and mixed by the purified heated air, and the adhesive solution is atomized and sprayed, so that several particles are aggregated into agglomerates containing the adhesive. The material is continuously dried, so that the moisture in the pellets evaporates and the adhesive solidifies. This process is repeated continuously to form ideal and uniform microporous spherical particles. There are two ports above the air filter, one is the air inlet and the other is the air outlet. After the air enters, it passes through the filter to filter out dust and impurities. After the heat exchange by the heater, the hot air enters from the bottom of the container. Pass through the bag filter, and finally discharge from the top; the container should be filled in an appropriate amount, generally 60%-80% of the volume, and the air inlet should have appropriate air intake and air pressure. The size of the air intake and air pressure can be based on the specific gravity of the powder Adjusting the size of the powder and the particle size, the appropriate air volume and air pressure can make the powder achieve a good boiling state; the top of the equipment is equipped with a bag filter with the filter bag mouth facing down, a small amount of fine powder will enter the bag filter together with the hot air, and the hot air will pass through the bag filter. The filter is discharged by the fan, and the fine powder is retained by the filter bag. The recoil device above the filter bag periodically blows back air to the filter bag to shake the filter bag and shake off the fine powder on it.
Dry granulation equipment is composed of feeding screw, extrusion wheel, pulverizer, particle container, etc. During operation, the evenly mixed material is added to the feeding hopper, and conveyed to the upper part of the two extrusion wheels through the screw for compression. The thickness is adjusted by the size of the gap between the two extrusion wheels, and the compressed material is pulverized into particles by a pulverizer in turn, and finally screened into particles with suitable particle size by a granulator.
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