GMP dust-free purification workshop crushing equipment

GMP dust-free purification workshop crushing equipment

The pulverization process of the GMP purification plant is mainly realized by the action of external mechanical force to destroy the cohesion between molecules, and is the basic operation for the production of solid preparations such as tablets, granules, capsules, and pills; The ingredients are mixed evenly, and the degree of mixing is consistent with...

Text label: GMP dust-free workshop equipment, purification pharmaceutical cleanroom crushing equipment, purification workshop engineering

GMP dust-free purification pharmaceutical cleanroom crushing equipment

The pulverization process of the GMP purification plant is mainly realized by the action of external mechanical force to destroy the cohesion between molecules, and is the basic operation for the production of solid preparations such as tablets, granules, capsules, and pills; The mixing of each component is uniform, and the mixing degree is related to the particle size of the component; it is conducive to dissolution or dispersion, the finer the solid material is crushed, the faster the dissolution or dispersion rate in the liquid, and the more uniform the dispersion; the finer the material is crushed , the better the bonding effect. In the process of pulverization, the solid powder that has reached the particle size requirement can be separated from the pulverizer in time, so that the coarse particles can continue to be pulverized, which can reduce the energy consumption of pulverization, and the powder that has reached the particle size requirement is still retained in the pulverizer. The operation of being crushed repeatedly before discharge is only suitable for crushing a small amount of material and it is hoped to complete all crushing in one operation. In the pulverized product, if there are materials that have not been pulverized, the coarse particles are separated by sieves or grading equipment and then returned to continue pulverizing. The larger the average particle size of the material, the higher the cost of grinding; the cyclic grinding can ensure that the product reaches the required particle size, which is suitable for grinding with higher particle size requirements.

The crushing operation of most materials is carried out in a certain dry state. Generally, the moisture content is usually less than 5%, which can be directly crushed. However, some materials with strong hygroscopicity need to be crushed using different Drying method can increase brittleness; wet grinding can reduce the adhesion of fine materials, so that only coarse particles can be left in the grinding area, avoiding the cushioning effect of fine materials, and avoiding dust flying. Low-temperature pulverization can be carried out by freezing raw materials, introducing refrigerant into the interlayer of the pulverizer, or mixing the materials with dry ice, liquid air, and liquid nitrogen and then pulverizing them. It can improve the production capacity of the pulverizer and reduce the energy consumption. The properties of the materials in the mixing and grinding should be similar, in order to achieve the same particle size of the crushed products. Mixing and grinding can avoid the sticking of some viscous materials or thermoplastic materials when they are crushed separately and the agglomeration between the materials. ;In order to reduce the sticking and agglomeration of the material during the grinding process, reduce energy consumption or make the product particle size finer, sometimes a small amount of grinding aid is added to the material; the addition of grinding aid can reduce the surface free energy of the particles, which is beneficial to The formation of new cracks can also reduce the adhesion of fine particles. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP purification workshops and GMP dust-free workshops.

GMP plant crushing equipment includes: hammer mill, axial flow impact mill, Shibata mill, rotary disc mill, ball mill, fluid energy mill, rolling mill, mortar mill; hammer There is a rotary disc that can rotate at high speed in the crushing chamber of the crusher, which is equipped with many movable steel hammers. When the rotary disc rotates, the steel hammers stand upright due to the centrifugal action, and the materials are strongly hammered, and the materials are fed from the hopper by the screw. The meter is quantitatively added, and crushed by the impact of the hammer, shearing, and the impact of being thrown to the lining plate. The principle of the axial flow impact pulverizer is the same as that of the hammer pulverizer. When the shaft rotates at a high speed, due to the action of the wind wheel, the material and air enter the machine at the same time, and the material is repeatedly impacted and sheared by the increasing peripheral speed. It is crushed by the impact of the cutting and lining plate, and is finally carried by the air and discharged from the outlet. The particle size of the crushed material can be changed by adjusting the gap between the blade and the lining plate; it is suitable for chemical, fibrous animal and plant medicinal materials with large output, etc. smash. The ball mill is composed of a cylinder made of stainless steel, pig iron or porcelain, with a certain number of steel balls or ceramic balls inside. The disadvantage is that the energy consumption is large, the intermittent operation, the loading and unloading is time-consuming, labor-intensive, and the crushing time is long; to crush the material to the micron level, a vibrating ball mill can be selected.

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