GMP workshop purified water preparation
The preparation of pure water in the GMP workshop should use drinking water as raw water, and use appropriate unit operations or combination methods. Commonly used methods for preparing purified water include membrane filtration, ion exchange, electrode deionization, distillation, etc., of which membrane filtration can also be used. Subdivided into microfiltration, ultrafiltration, nanofiltration and reverse osmosis...
Text label: GMP workshop engineering, GMP workshop pure water preparation
Preparation of purified water in GMP pharmaceutical cleanroom
Preparation of pure water in GMP pharmaceutical cleanroom should use drinking water as raw water, and adopt appropriate unit operation or combination methods. Commonly used methods for preparing purified water include membrane filtration, ion exchange, electrode deionization, distillation, etc. Among them, membrane filtration The method can be subdivided into microfiltration, ultrafiltration, nanofiltration and reverse osmosis. The reverse osmosis device adopts reverse osmosis, the most sophisticated membrane liquid separation technology, which only allows water molecules to pass through and does not allow solutes to pass through a semi-permeable membrane; when the pretreated water enters the reverse osmosis system, most ions and bacteria can be removed. At the same time, it can effectively remove microorganisms and TOC, etc., and achieve high-standard water quality requirements of continuous and stable low conductivity and low bacterial content.
The selection of purified water preparation process needs to consider factors: the quality of raw water, the owner's requirements for water quality, measures to prevent microbial contamination and disinfection, equipment operation and the professional quality of operators, the ability to adapt to changes in raw water quality in different seasons and Reliability, convenience of daily maintenance of equipment, water recovery rate of equipment and treatment of waste liquid discharge, daily operation and maintenance cost, system monitoring ability; pretreatment unit generally includes multi-media filter, activated carbon filter, softener The main purpose of the pretreatment unit is to remove insoluble impurities, soluble impurities, organic matter and microorganisms in the raw water, so that the main water quality parameters can meet the water inlet requirements of the subsequent purified water system, thereby effectively reducing the subsequent purification system. Work load , to prevent pollution or irreparable damage to the purification system; most of the multi-media filters are filled with quartz sand, and the quartz sand should be filled sequentially according to the particle size from the bottom to the top. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and clean workshops. The purified water system generally has various processes such as RO→RO→EDI, RO→RO, RO→EDI, etc. The purification system “purifies” the pretreated water to meet the internal control requirements through the key process of deionization, reduction of organic matter and microorganisms. Purified water, the ability to remove residual chlorine is the main indicator of activated carbon.
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