How to deal with the tablet weight of the pharmaceutical tablet press_Tablet press_high speed_single punch_double layer_flower basket_multifunctional rotary tablet press PHARM

How to deal with the tablet weight of the pharmaceutical is out of tolerance

How does PHARMA Tablet Press machine Machinery Manufacturing Co., Ltd. deal with the out-of-tolerance tablet weight of pharmaceutical tablet presses?

1. The particle size distribution is uneven. The particle flow rate is different when the pharmaceutical is compressed, resulting in uneven particle size filled into the die hole. The particles should be mixed or sieved to remove excessive fine powder.

2. When the fine powder adheres to the punch and causes the punch to hang, the difference in tablet weight can be large. Solution: At this time, the rotation of the lower punch is not flexible, and it should be checked in time, remove the die, and clean the lower punch and the middle die hole

3. The fluidity of the particles is not good, and the particles flowing into the middle die hole are sometimes more and sometimes less, causing the difference in tablet weight to be too large and exceed the limit. Solution: re-granulate or add a suitable glidant such as micronized silica gel

etc. to improve particle fluidity.

4 particle layering. Pharmaceutical solution: Particle layering to reduce particle size difference.

5 Smaller tablets use larger particle materials. Solution: choose the appropriate size of particles.

B The hopper is blocked. This phenomenon often occurs with viscous or hygroscopic drugs. Solution: The hopper should be dredged, the pressing environment should be kept dry, and a glidant should be added to solve the problem.

7 There is a large difference in the amount of material stored in the material. Solution: control within 50%.

8 The feeder is unbalanced or not installed in place, resulting in uneven filling. Solution: Balance the feeder or install it in place.

9 The powder scraping plate of the pharmaceutical is uneven or poorly installed. Solution: Leveling.

10 The punch of the pharmaceutical does not fit well with the die hole. Solution: For this, the punch and die should be replaced.

11 The length of the lower punch is different and out of tolerance, resulting in uneven filling. Solution: fix the difference, the difference is within 5 to m.

12 The damping force adjusted by the damping screw with damping of the lower punch of the pharmaceutical is not good. Solution: readjust.

13 The filling track is worn or the filling mechanism is unstable. Solution: replace or stabilize.

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