How to Prevent Clean Room Cross Contamination?

Clean room is an independent space built for safe production and experiments. It is widely used in laboratories, food industry, medical industry, bio-pharmaceutical industry, high-precision electronics industry, etc. In order to achieve a dust-free clean room, prevention work must be done. Today I will introduce to you how to prevent cross contamination in the clean room.

Arrange a suitable layout route during the design stage of the clean room. According to the work process, the overall inlet and outlet line design is to avoid unnecessary air flow caused by workers going back and forth multiple times. Make full use of the available area for reasonable layout, raw material area, production area and finished product area must have clear boundaries to minimize cross contamination. The area of the clean room cannot be reduced blindly, it should be set according to the purpose of use, the number of internal machines, the size of the machine, and the number of workers.

The clean room air conditioning purification system is the primary factor that determines the cleanliness of the clean room. The function of the air conditioning purification system is to transport clean air to the clean room through the air supply system, dilute the air containing bacteria and dust in the clean room and enter the return air system, then mix it with the treated fresh air and transport it into the clean room again. The air purification system is a cyclic process that controls the cleanliness level within the required range. For serious pollution hazards, flammable and explosive toxic gases or toxic gases, if they still do not meet the circulation requirements after treatment, they need to be eliminated separately.

Improving the automation and self-purification of equipment is also an effective way to prevent cross contamination. Automated production line equipment can reduces the work of people, thereby reducing air flow and cross contamination caused by walking. Use equipment with self-cleaning functions as much as possible, such as self-cleaning pass box, self-cleaning air shower. For machines that may cause dust pollution, such as grinder, tablet press machine and filling machine,  can choose models with isolation covers, or can concentrate them in one room to reduce the flow of pollutants.

Pay attention to the flow of people and objects in the clean room. People must pass through the air shower room before entering the clean room, shoes must be treated with sticky mats. Gloves, masks, hats, clean clothes are essential. Strictly control the number of people entering the clean room, do not enter unless necessary. People entering the clean room can only stay in their own work area and are not allowed to walk around at will. Goods must also be purified through the cargo air shower room before entering the clean room. Goods should be transferred between clean areas and non-clean areas, clean areas and clean areas, and between areas of different cleanliness levels through pass box.

Strictly controlling cleanliness and preventing contamination and cross-contamination are the core elements of creating a GMP clean room, which requires the joint efforts of all users.