Introduction of sterilization in purification workshop
Introduction of sterilization in purification workshop
Sterilization in the purification pharmaceutical cleanroom is to remove all microbial propagules and spores, including bacteria, fungi, etc. Different types of microorganisms, different sterilization methods, and different sterilization effects. Dry heat sterilization is the use of flame or dry hot air for sterilization; flame sterilization is sterilized by burning directly in the flame...
Text label: purification workshop installation engineering, purification workshop sterilization, purification workshop design
Introduction to sterilization in purification workshop
Sterilization in the purification workshop is to remove all microbial propagules and spores, including bacteria, fungi, etc. Different types of microorganisms, different sterilization methods, and different sterilization effects. Dry heat sterilization is the use of flame or dry hot air for sterilization; flame sterilization is a method of burning sterilization directly in a flame. The sterilization is rapid, reliable and simple. It is suitable for utensils such as metal, glass and porcelain that are resistant to flame sterilization, but not suitable for the sterilization of medicines. Dry hot air sterilization is sterilization in high temperature dry hot air. Due to the strong heat resistance of the cell wall of microorganisms in a dry state, it takes a long time to heat to achieve the purpose of sterilization; dry heat sterilization at 135-145 ℃ requires 3-5H, 2-4H for 160-170℃, 0.5-1H for 180-200℃; this method is suitable for high temperature resistant glass products, metal products and greases that do not allow moisture to penetrate and high temperature resistant sterilization The disadvantage is that the penetrating power is weak, the temperature is not easy to be uniform, and the sterilization temperature is high and the time is long, so it is not suitable for the sterilization of rubber, plastics and most drugs.
Moist heat steam sterilization is sterilized in saturated steam or boiling water or circulating steam. Due to the large latent heat of steam and strong penetrating power, it is easy to denature or solidify proteins, so the sterilization efficiency is higher than that of dry heat method. Autoclave sterilization uses saturated steam with a pressure higher than normal pressure to kill microorganisms. This method has strong sterilization effect, reliable sterilization, and can kill all bacterial propagules and spores. It is the most widely used in preparation production. A sterilization method; all preparations that can withstand high pressure steam, glass containers, metal containers, porcelain, rubber stoppers, membrane filters, etc. can use this method. After the ampoules are filled and sealed, it is necessary to conduct leak detection, and check the tightness of the ampoule seal to ensure the airtightness after filling. Slightly open the pot door, pour cold water into the ampoules from the water inlet pipe to rinse the ampoule to reduce the temperature, then close the pot door tightly and pump air to reduce the pressure in the sterilizer. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and clean workshops.
Circulating steam sterilization refers to the method of sterilizing microorganisms by circulating steam at 100°C under normal pressure, usually for 30-60min. It is suitable for temporary instruments or preoperative disinfection, but not suitable for the production of preparations. Low temperature intermittent sterilization, heat the items to be sterilized with 60-80 ℃ water or circulating steam for 1H, kill the cell propagules, and then place them at room temperature for 24H, let the spores develop into propagules, and heat again. Sterilization, repeat 3-5 times until the spores are eliminated; this method is suitable for sterilization of preparations that are not resistant to high temperature, but the disadvantage is that it is time-consuming and low in work efficiency, and the sterilization effect of spores is often unsatisfactory, but it is often used in bacterial inspection. Use this method.
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