Large infusion dust-free clean workshop
Large infusion dust-free clean pharmaceutical cleanroom
Large infusion packaging containers mainly include glass bottles, plastic bottles and plastic bags; PVC soft bags have good stability at room temperature, are easy to transport, are relatively soft, and are not easy to enter air during use, but have poor compatibility , Water vapor permeability is also high; semi-hard plastic bottles made of PP and PE...
Text label: Large infusion clean pharmaceutical cleanroom, large infusion clean workshop
Large infusion dust-free clean workshop
Large infusion packaging containers mainly include glass bottles, plastic bottles and plastic bags; PVC soft bags have good stability at room temperature, are easy to transport, are relatively soft, and are not easy to enter air during use, but have poor compatibility , The water vapor permeability is also high; although the semi-rigid plastic bottles made of PP and PE do not have the problem of PVC bags, but because they are semi-rigid, they need air into the holes like glass bottles during infusion, and there are also polluted danger. The multi-layer co-extrusion film adopts the multi-layer co-extrusion technology and is manufactured in a clean environment using a special process. It is composed of PP and PEBS in different ratios. It is extruded from a closed tube in a clean environment. The film bag composition will not enter, and the inside of the film cylinder is filled with 100-grade clean air. In addition, the high-temperature extrusion process ensures the surface of the film. Sterility, can meet various requirements of infusion bags, can be sterilized at 121 ℃, soft, transparent, and low water vapor permeability.
The glass bottle filling process consists of water production, pretreatment of empty infusion bottles, treatment of rubber stoppers and isolation films, ingredients and finished products. Before filling and sealing, 4 production paths are carried out at the same time. The solvent preparation of injection, Treatment of empty infusion bottles, treatment of rubber stoppers, preparation of infusion agents; in order to remove impurities such as additives in the rubber stopper, it is necessary to clean the rubber stopper, which can be carried out on a rubber stopper cleaning machine. After the purified water is boiled, the impurities of the rubber stopper are removed, and then it can be used after cleaning with purified water and water for injection. The requirements for raw and auxiliary materials, production equipment and production environment are higher, especially the condition control of the production environment, such as the filling, filming, and plug-turning processes of the infusion agent, and the environment is required to be local level 100. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for large infusion dust-free workshops and clean workshops.
Infusion filling of non-PVC soft bags in clean workshops generally starts from bag making, unwinding → printing → shape sealing → trimming → interface feeding, positioning → interface sealing → upper bag sealing → final sealing → bag output → bag storage → input Bag→vacuum or nitrogen inlet→filling→capping→outlet bag; bag making, filling and sealing are completed on a mechanical device in a controlled environment of class 10000 (filling and sealing are carried out under the protection of local 100-class laminar flow) . The difference between the plastic bottle filling process and the glass bottle filling process lies in the bottle processing process. The plastic particles are injected into the preform, the inner and outer caps and the rings. The preform is blown to form a plastic bottle, and then the bottle is washed, filled, and capped. , add the rings to form the finished product.
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