Large infusion production sterile purification workshop equipment
Large infusion production sterile purification workshop equipment
The large infusion production purification workshop mainly adopts the sterilization production process, and the packaging of the infusion is usually made of glass bottles, plastic bottles and plastic bags. The infusion filling equipment is to pour the prepared liquid into the container. The filling machine has many forms, and there are linear rooms according to the movement form...
Text label: Large infusion production purification workshop, large infusion production sterile workshop, sterile workshop equipment
Aseptic purification workshop equipment for large infusion production
The large infusion production purification pharmaceutical cleanroom mainly adopts the sterilization production process, and the packaging of the infusion is usually made of glass bottles, plastic bottles and plastic bags. The infusion filling equipment is to pour the prepared liquid into the container. The filling machine has many forms. According to the movement form, it can be divided into linear intermittent movement and rotary continuous movement; according to the filling method, it can be divided into atmospheric filling, negative There are 4 types of pressure filling, positive pressure filling and constant pressure filling; according to the metering method, there are three types: flow timing type, measuring cup volume type, metering pump injection type, such as plastic bottles, modern devices are often formed on blow molding machines Immediately after filling and sealing in the mold, it is easier to achieve aseptic production.
After the liquid medicine is filled, it must be sealed immediately in the clean area to prevent pollution and oxidation. The sealing machine is used in conjunction with the filling machine. The sterilization process is very important to ensure the quality of large infusions. Commonly used are high pressure steam sterilization and water bath sterilization. Water bath sterilization equipment includes water bath sterilization cabinet and rotary water bath sterilization cabinet. The water-bath sterilizer uses deionized water as the heat transfer medium, uses the heat transfer medium to heat the infusion bottle, and kills microorganisms through high temperature; uses clean deionized water as the three-stage heating, heat preservation and cooling for the infusion bottle. The heating and cooling of the heating medium are carried out in the plate heat exchanger outside the cabinet; the water bath sterilizer is composed of a rectangular cabinet, a hot water circulation pump, a heat exchanger and a microcomputer control cabinet ; In the sterilizer, the circulating hot deionized water is used to achieve the purpose of sterilization through a water bath; the working process of the water bath sterilizer is fully automatic program control, equipped with special automatic control equipment, using industrial PC, four-channel recording The sterilization parameters such as temperature, pressure and other sterilization parameters are displayed by digital instruments and monitors, and the beeper will send a signal when the sterilization is over or a fault occurs. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for large infusion production purification workshops and sterile workshops.
The rotary water-bath sterilizer is mainly used for the sterilization of fat emulsion infusion and other suspension infusion formulations. It not only has all the performance and advantages of the water-bath sterilizer, but also has its own unique advantages. , rotating inner cylinder, deceleration transmission mechanism, hot water circulating pump, heat exchanger, industrial computer control cabinet, etc.; the circulating water of the industrial computer controlled sterilizer is heated, constant temperature and cooled by the heat exchanger; the circulating water is heated from the top and both sides Spray the liquid medicine bottle, rotate with the drum in the cabinet, heat transfer is fast, the temperature is uniform, and the sterilization effect is ensured; the circulating water is heated to the sterilization temperature through the heat exchanger, and the sterilization temperature is maintained; the circulating water is circulated and cooled through the heat exchanger When the temperature is about 50°C, if the temperature of the bottle is set below 20°C, the cold water valve is closed, the chilled water or low-temperature water valve below 5°C is opened, the circulating water is cooled to the bottle-out temperature through the heat exchanger, and the low-temperature water valve is closed. The water pump stops working. There is a rotating inner cylinder in the rotary sterilizer, the speed of the inner cylinder is infinitely adjustable, the glass bottle is fastened on the trolley, the trolley and the inner cylinder are pressed together, and the content rotation has a quasi-stop device, which is convenient for the trolley to enter and exit the cabinet. ; Adopt advanced sealing device, magnetic drive, no leakage and no pollution in the sterilization process.
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