Precautions for pressure adjustment and use of automatic tablet press
1. The surface of the punch of the tablet press is damaged or the surface finish is reduced, there may also be anti-rust oil or lubricating oil, the surface of the new die is rough, or the lettering is too deep and angular. You can clean the punch, replace the substandard die, or rub a small amount of liquid paraffin on the surface of the lettering punch to lubricate the lettering. In addition, if sticking is caused by mechanical heating, the cause should be checked and the pharma machinery repaired. 2. The design of engraved and stamped characters is unreasonable. Replace the punch or change the character design accordingly. 3. Too much water content in the granules or uneven dryness and wetness of the granules cause stickiness. Solution: Control the moisture content of the granules at about 2% to 3%, and strengthen the inspection of dry granules. 4. Insufficient amount of lubricant or improper selection, too much fine powder. The amount of lubricant should be appropriately increased or replaced with new lubricant to remove excessive fine powder. 5. The large difference in the fineness of raw and auxiliary materials results in uneven mixing or improper mixing time. Solution: crush and sieve the raw and auxiliary materials to make the fineness meet the quality requirements of the variety, and at the same time master and control the mixing time. 6. The concentration of the adhesive is low or the adhesive force is poor due to the quality of the adhesive. There are too many fine powders (over 10%) and sticky. Solution: Use a 40-mesh sieve to sieve the fine powder and re-granulate, dry, granulate, mix the whole batch evenly, and then press into tablets. 7. Sticking is caused by the raw material itself (such as hygroscopicity). Solution: add a certain amount of absorbent (such as adding 3% calcium hydrogen phosphate) to avoid sticking. 8. The ambient humidity is too high, and the humidity is too high to reduce the ambient humidity. 9. If the operating room temperature is too high, it is easy to cause sticking. Attention should be paid to reducing the operating room temperature.
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