Present situation of tablet press at home and abroad

Domestic status quo (1) There are many specifications and large quantities of tablet presses. Although the tablet press is the pharmaceutical equipment with the longest production history in my country, it is also the pharmaceutical equipment with the earliest export and the largest output. According to incomplete statistics: there are nearly 40 tablet press manufacturers in my country, with an output of nearly 2,000 units per year, and as many as 60 product specifications, which can press round tablets, engraved tablets, special-shaped tablets, double-layer tablets, multi-layer tablets, and ring-shaped tablets. chip, package chip and other chip types. It is an indisputable fact that the number, variety, specifications and output of tablet press manufacturers rank first in the world. (2) Easy to operate. In recent years, tablet press manufacturers have begun to pay attention to product quality, and most of them believe in“win by quality”business concept. Aiming at the characteristics of numerous domestic pharmaceutical manufacturers, various types of tablets, and small production scale. As a tablet press manufacturer, the tablet press products developed have the characteristics of simple operation, convenient and quick cleaning, especially when changing varieties, the clearing is quick and convenient. (3) The technical content is low, and the force behind technological innovation is insufficient. At present, more than 40 domestic pharmaceutical pharma machinery companies produce more than 60 varieties and specifications of tablet presses. Although, new products are constantly being launched every year. But among them, there are varieties with high technical level and high added value. Repeated product development is serious, plagiarism is prevalent, and there are as many as dozens of tablet press manufacturers of a certain type. In order to survive, many small-scale pharmaceutical equipment enterprises not only adopt“imitation”strategy, some manufacturers even rely on copying other people's technology as their own“innovation”, and some even in“Shoddy”. In order to compete for orders, prices are often lowered, because brand loyalty is low. After the price war started, these brands suffered even more, and now the brand is constantly depreciating. If this situation is not reversed, it will inevitably lead to the overall regression of the design and manufacturing level of tablet presses in my country. The vast majority of enterprises in our country are private enterprises, which do not have advantages in technology, equipment, talents, etc., which seriously restricts the technological innovation of enterprises. Some enterprises lack research and development institutions, the innovation system is not perfect, technical personnel lack awareness of technological innovation, the overall technical strength of the enterprise is not strong, and the update speed of scientific research and production technology equipment is very slow. The most noteworthy thing is that the technological talents of the entire industry are in a“blue and yellow”stage. It can be said that the talent crisis is spreading throughout the industry. The current situation of foreign tablet presses The gap between our tablet presses and tablet press technology in developed countries is still widening. High-speed, high-yield, airtight, modular, automated, large-scale and advanced testing technologies are the most important technologies for foreign tablet presses. direction of development. Advanced tablet presses are basically produced in Europe and the United States, such as FETTE and KORSCH in Germany, MANESTY in Britain, COURTOY in Belgium, and STOKES in the United States. Its products have high automation procedures and meet the requirements of FDA and 21CFRPART11. (1) High speed and high output. High speed and high output are the goals that tablet press manufacturers have been pursuing for many years. At present, the major tablet press manufacturers in the world have tablet presses with an hourly output of 1 million tablets. For example, the Xpress700 tablet press produced by Manestry has a maximum output of 1 million tablets; the XL800 tablet press produced by Korsch has a maximum output of 1.02 million tablets/h; the ModulD tablet press produced by Courtoy has a maximum output of 107 10,000 tablets/h; the 4090i tablet press produced by Fette Company has a maximum output of 1.5 million tablets/h. Its output is much higher than that of domestic tablet presses. To catch up with foreign countries in terms of speed and output, domestic tablet presses need to make great progress in tablet press design innovation, processing technology, and automatic control. (2) The airtightness of the tableting process and the isolation of the flow of people and goods. The airtightness of the input and output of foreign tablet presses is very good, reducing cross-contamination as much as possible. The granules used for tableting enter the hopper through a closed material barrel and a closed conveying system. During the tableting process, effective measures are taken to prevent dust from flying and particle stratification. The pressed tablets enter through sieves, in-tablet detection, metal detection, etc. Packaging process, the whole process is quite airtight. However, most of the domestic tablet presses are open in the tablet pressing process, or there is no airtight seal, and the broken process causes dust to fly between the tablet presses. With the in-depth implementation of GMP, the airtightness of the tableting process and the isolation of people and logistics have become particularly important. This is the basic function that we must have in designing and manufacturing pharma machinery. (3) Cleaning in place. WIP (cleaning in place) tablet press greatly reduces the cost of user equipment. To improve the cleaning function of the tablet press, in addition to fully considering the cleaning of each part in the design, the cleaning function of the tablet press emphasizes detachability. Only convenient and quick disassembly can ensure clear safety.

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