Selection of pipes and valves in GMP purification workshop
Selection of pipes and valves in GMP purification workshop
The material selection of pipes, valves and fittings used in the pharmaceutical industry of GMP purification pharmaceutical cleanroom is mainly based on the comprehensive consideration of factors such as the concentration, temperature, pressure, corrosion, supply source and price of the conveying medium; regardless of the strength of the medium, if Adjacent upper and lower two thick...
Text label: GMP purification workshop installation, GMP workshop pipeline valve, GMP pharmaceutical cleanroom setup and installation
GMP purification workshop piping and valve selection
The material selection of pipes, valves and fittings used in the pharmaceutical industry of GMP purification pharmaceutical cleanroom is mainly based on the comprehensive consideration of factors such as the concentration, temperature, pressure, corrosion, supply source and price of the conveying medium; regardless of the strength of the medium, if If the corrosion resistance of the adjacent upper and lower concentrations is the same, the corrosion resistance of the middle concentration is generally the same. If the corrosion resistance of the upper and lower concentrations is different, the corrosion resistance of the middle concentration is often between the two. In general, corrosivity increases with increasing concentration. In general, the higher the temperature, the greater the corrosiveness. When the lower temperature indicates no corrosion resistance, the higher temperature is not corrosion resistant. When the corrosion resistance of the upper and lower adjacent temperatures is the same, the middle temperature The corrosion resistance is also the same, but if the corrosion resistance of the upper and lower temperatures is different, the low temperature corrosion resistance, the high temperature corrosion resistance, the higher the temperature, the faster the corrosion rate; in the actual use process, it is likely that due to fluctuations in production conditions, Or due to seasonal or regional changes in temperature and humidity, as well as evaporation, water absorption, venting or liquid level rise and fall during storage and transportation, resulting in changes in local concentration and temperature, so that it is easy to reach the concentration or temperature limit range that is not resistant to corrosion. .
The commonly used pipes in the pharmaceutical industry include metal pipes and non-metallic pipes. Commonly used metal pipes include cast iron pipes, ferrosilicon pipes, seamless steel pipes, non-ferrous metal pipes and lined steel pipes; commonly used non-metallic pipes include glass pipes, Rigid PVC pipe, polyethylene pipe, plexiglass pipe, rubber pipe and lined pipe. The function of the valve is to control the flow of fluid in the pipe, and its functions include opening and closing, adjustment, throttling, self-control and safety assurance. Valves have different use characteristics, use occasions and installation requirements due to different structural forms and materials. Selection principles: fluid characteristics, whether it is corrosive, whether it contains solids, viscosity and whether there will be phase changes during flow; function According to the requirements of the process, it is clear whether to cut off or adjust the flow, etc.; temperature and pressure, the temperature and pressure level of the valve are determined by the temperature and pressure of the medium; the valve size is determined by the fluid flow and allowable pressure drop; resistance loss, according to the process Choice of allowable pressure loss and functional requirements. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP purification workshops and dust-free workshops.
The basic methods of pipeline connection include threaded connection, flange connection, socket connection and welding, ferrule connection and clamp connection, ferrule connection is a common connection between small diameter pipelines, valves and pipe fittings It has the advantages of simple connection and convenient disassembly and assembly, and is often used for the connection of pipelines such as instruments and control systems; the clamp connection is to insert a metal pipe into a non-metallic hose, and fasten it with a metal hoop outside the insertion port to prevent The medium leaks out; the clamp connection has the advantages of flexible disassembly and assembly, economical and durable, and is often used for the connection of temporary installations or clean material pipelines.
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