Summarize several reasons for the slivers of high-speed tablet presses1
The high-speed tablet press suppresses various granular raw materials into round tablets and special-shaped tablets. It is the basic pharma machinery suitable for mass production. Its structure is double-press, with two sets of feeding devices and two sets of wheels. The depth of filling and the thickness of the tablet can be adjusted. The mechanical buffer device on the machine can avoid damage to the parts caused by the load. The body is equipped with a powder suction box, which can absorb the smoke and dust formed when the pharma machinery is running according to the suction nozzle, so as to prevent adhesion blockage and recycle raw materials for reuse. The high-speed tablet press can suppress various powder and granular raw materials into tablets of different shapes such as round and special-shaped. At present, there are different pressure specifications such as 1.5T5T6T, and the thickness of the tablet, the pressure size, and the depth of material filling can be adjusted according to the needs of customers. This machine is a desktop continuous feeding production type tablet press machine, which can also be manually operated to produce tablets when the power supply is lacking. The pressed tablets have average thickness and high gloss without polishing. It can be widely used in chemical plants, pharmaceutical companies, laboratories, university research institutes, pharmacies, etc. to inhibit various sheet applications. The lobes refer to the lobes that are split from the waist when they are vibrated or placed, and the ones that are split from the top are called top cracks. The waist and top cracks are collectively called lobes. 1. If the pressure is too high, the pressure on the particles will increase, and the expansion level will also increase. The binding property of the adhesive cannot inhibit its expansion, so it will cause slivers, and the pressure should be reduced to solve it. 2. The upper punch and the die hole do not meet the requirements. The punch die that has been used for a long time is gradually damaged, causing the upper punch and the die hole to be inconsistently matched. The upper punch contains sharp inward curls, and the pressure is uneven, which makes the part of the film under too much pressure, causing top cracking or die ring walking. Out of shape. 3. The speed of the high-speed tablet press is too fast, and the compression time of the sheet is too short, so that the film is suddenly compressed and compressed, and then suddenly expands and splits. Correspondingly, if there is preload, increase the preload time. 4. Improper selection of binder, less binder during granulation, insufficient viscosity means that the granules are dried, and too much fine powder means that the dry granules are too hard, which may cause difficulty in dissolving and one-sided pitting, so the addition of binder should be appropriate ; If there are too many fine powders, a small amount can be sifted out; if the granules are too hard, they should be repaired and granulated again and the disintegrant should be added. 5. Particles do not conform to the regulations, the material is loose, and there are too many fine powders to cause slivers. The improvement method should be to adjust the concentration and dosage of the binder, and improve the granulation method to overcome it. 6. The granules are too dry, and the medicine containing crystal water loses too much, resulting in slivers. The solution is the same as that of loose flakes. 7. Some crystalline drugs have not been sufficiently broken. Such medicines can be sufficiently crushed and then granulated. 8. The room temperature is low and the humidity is low, which is easy to cause cracks, especially for drugs with poor viscosity. Adjust the temperature and humidity system accordingly.
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