In this busy world we live in, finding time to clean the residence is more and more often in the bottom one's long 'to do' number! Most families nowadays have two working parents with hardly enough time in the day for a fine dinner. Purchase encourage everyone to help, set time limits on each room, you can get your house and keep the house clutter free the actual world week. Even younger children can have access to small jobs that they will be effective at do, in addition as in the end feel good about previously being asked assist you.

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Do useful area clean. Don't leave your old dusty furnace filters or broken furnace parts lying around the furnace room. Not only does this clutter up the area, around the other hand cleanroom workshop can also create a hearth hazard.

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Granule clean pharmaceutical cleanroom

Granulation is an important link in the production of solid preparations. It is divided into two categories: wet granulation and dry granulation. The shape and size of granules produced by different granulation technologies are different. , material properties, etc.; wet granulation is the addition of wetting agent or liquid viscosity to the material...
Text label: clean workshop workshop, granule clean workshop, granule clean workshop

Granule clean workshop


Granulation is an important link in the production of solid preparations. It is divided into two categories: wet granulation and dry granulation. The shape and size of granules produced by different granulation technologies are different. , material properties, etc.; wet granulation is a method of adding wetting agents or liquid binders to granulate materials to obtain uniform particle size, good compressibility, fluidity, and strong wear resistance; extrusion granulation It is a traditional granulation method, which can control the pore size adjustment of the screen according to the size and softness of the particles, and add different adhesives for granulation. Continuous production requires frequent replacement of the screen; making soft material is a key step in extrusion granulation. hard.


Making wet granules is to forcibly extrude the obtained soft material through a screen with a certain size of aperture to make wet granules. The wet granules should be uniform in size, less fine powder and no long strips. The commonly used equipment in production is swing type In the granulator, the granules should be dried, preferably at 50-60 °C. During the drying process, some granules may stick together, so give proper granulation, and finally obtain uniform granules with a certain particle size. The material is put into the high-speed stirring and granulating container, and the binder is added after stirring and mixing. The commonly used high-speed stirring granulator is divided into two types: horizontal type and vertical type. The structure is mainly composed of mixing tank, stirring blade, cutting knife, etc. The main factors affecting particle size and compactness are the type of binder and the amount added. According to the mixing method, stirring speed, particle size of raw material powder, etc., the prepared wet granules need to be dried and granulated. High-speed stirring and granulating, mixing, kneading and granulating in one container, the operation is simple and fast; granules with different tightness can be prepared; the preparation process is airtight to avoid pollution and dust flying; the growth process of granules is not easy to control. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean workshops and clean workshops.














Dry granulation is to mix the materials evenly, press them into blocks, flakes, etc. with suitable equipment, and then crush them into particles of suitable size. No wetting agent or liquid binder is required in the granulation process. It also does not need to be dried, and is often used for granulation of heat-sensitive materials and easily decomposed materials in contact with water. 20-25mm in diameter, and then crushed into particles of the required size. This method is simple to operate, but the pressure is high, the die and other mechanical equipment are easily damaged, and the raw materials are also lost to a certain extent; the rolling method is to mix the drug with the material powder. After homogenization, it is pressed through the gap between two rolling cylinders with the same rotation speed to form a sheet of required hardness, and then broken into particles of a certain size.
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Clean workshop project acceptance
The inspection of clean workshop engineering acceptance and routine inspection should be empty or static, and the inspection and monitoring of use acceptance should be dynamic. When necessary, the inspection can also be determined through negotiation between the construction party, the construction party and the inspection party state. The wind system is a hidden project, and the general clean workshop project...
Text label: clean pharmaceutical cleanroom acceptance, clean engineering acceptance, clean workshop engineering

Clean workshop project acceptance


The inspection of clean workshop engineering acceptance and routine inspection should be empty or static, and the inspection and monitoring of use acceptance should be dynamic. When necessary, the inspection can also be determined through negotiation between the construction party, the construction party and the inspection party state. The air system is a hidden project. After the interior of the general clean workshop project is completed, it is difficult to adjust the quality of the air system. In order to ensure that the indoor environment required by the project can meet the standards and meet the needs of users, the air system needs to be divided. project acceptance; the thickness, combustion performance and corrosion resistance of the air duct and its thermal insulation materials shall meet the requirements of fire protection regulations; the air duct shall be provided with pre-buried pipes or protective casings, pre-buried pipes or protective sleeves when passing through walls and fire zones. The wall thickness of the pipe steel plate should not be less than 1.6mm, the gap between the air duct and the casing should be sealed with non-combustible flexible materials that are harmless to human health, then sealed with sealant, and finally the surface is decorated.


The length dimension of the inner side of the frame opening for installing the high-efficiency filter shall not be positive deviation, and the allowable negative deviation shall not be greater than 3mm; the frame for installing the high-efficiency filter shall not be flat, and the allowable deviation of the flatness of the installation frame of each high-efficiency filter shall It is 1mm; after the high-efficiency filter is installed and before the comprehensive performance measurement, it is not suitable to install the diffuser plate and decorative layer; the high-efficiency filter for sending and exhausting the air is used for the purpose of filtering biological aerosols, and it is a clean workshop of grade 5 or above or Air supply end high-efficiency filters with special requirements should be scanned on-site one by one to detect leaks, and should be qualified. For clean rooms below level 5 whose main purpose is to filter non-biological aerosols, air supply high-efficiency filters or their end devices are installed. On-site scanning should be carried out to detect leaks, and the leak detection ratio should not be lower than 25%; the resistance of the high-efficiency filter installed in each independent clean environment should be reasonably adjusted. Between the filters, the difference between the rated resistance of each set and the average value of the rated resistance of each set should be less than 5%. During the acceptance process, the actual measured value of the high-efficiency filter product should be checked; about the number of tests, according to the order for installing multiple filters. 20% of the number of air inlets or air supply surfaces shall be sampled, but not less than one air supply outlet or air supply surface; for the dynamic air flow sealed return and air outlet high-efficiency filter devices with differential pressure gauges, the air supply shall be sent to Wind pressure test, the reading of the differential pressure gauge should be above 10Pa, and all air outlets with differential pressure gauge should be checked during the test and observation. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean workshops and clean projects.














The test items that should be adjusted during the operation confirmation during the completion acceptance include: detection of the rotation number, air volume and outlet static pressure of the fan; measurement and balance of the air volume of the system and each room; detection and adjustment of the static pressure difference between the same rooms; Adjustment system linkage operation, precise setting and adjustment; temperature and humidity setting and adjustment; scanning leak detection of all high-efficiency filter installation frames and filter element bodies; indoor air cleanliness level; switching inspection of different operating conditions specified in the design. The contents that need to be tested for the performance acceptance of clean pharmaceutical cleanroom or clean area include: air cleanliness test, planktonic bacteria and sedimentation bacteria concentration test should be carried out in biological clean workshop; static pressure difference test; wind speed or air volume test.
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Filter leak detection I believe that many companies will have questions about how to detect leaks in filters. Guangdong Saite purification generally adopts the following methods. According to the 'Clean Room Construction and Acceptance Specifications', the leak detection of the high-efficiency filter can have the following methods: 1. The leak detector method to scan the leaked filter must have measured the air volume, which is between 80% and 120% of the designed air volume. conduct. When there are multiple filters on the same air supply surface, the method of exposing only one filter at a time should be used for measurement if the structure allows. When several or all filters must be exposed to aerosol at the same time, in order to uniformly mix all filters, it is advisable to introduce aerosol for leak detection at the suction end of the fan or the branch pipe in front of these filters, and immediately check the The concentration on the windward side is measured directly in front of the filter. 2. Leak detection by particle counter method The air volume of the leak-detected filter must have been measured, and the air volume should be between 80% and 120% of the design air volume. The instrument is a light-scattering particle counter with a sampling volume of 1-3L/min that can measure 0.5 microns. For leak detection, bulk particle counters are not suitable. Now it should be explained that it is not easy, unnecessary, and even less intuitive to use the DOP method for leak detection on site, because it reflects the relative value of the concentration rather than the amount of particles. In addition, DOP brings pollution to the filter, whether it has carcinogenic effect is still a question. It turns out that both leak detection methods require a certain upstream concentration, which is based on the minimum scale of the instrument, the efficiency of the high-efficiency filter is defined as 99.97%, and the minimum reading of the particle counter is 1 particle. However, the latest research and measurement practice show that the upstream concentration is not necessary to be so large, and it should be enough to bring danger to the work area, and it does not matter if it cannot be measured. According to experiments, the upstream concentration of the high-efficiency filter may be about 3000 grains/L. The calculation shows that for a leak as small as 0.2mm, at a distance of 25mm from the filter surface (this is the common requirement of relevant standards at home and abroad), when sampling at a flow rate of 2.83L/min, a concentration of about 25 grains/L will be obtained. , which is completely measurable. 3. The construction acceptance specification stipulates that the number of particles detected by the particle counter during leak detection is not greater than 3 times or 2 times the theoretical number of particles that can pass through (the latter is for ultra-high efficiency filters). The basis for this is the calculations presented by the authors. However, according to the latest research above, for an ordinary 0.5-micron high-efficiency filter with class 100 as the highest object, if the number of particles measured at a distance of 25mm from the filter surface does not exceed 3 particles/L, it will not bring the work area. The danger of exceeding the standard, so this can be used as a leak detection standard for ordinary high-efficiency filters. 4. For the 100-level sites, there must be a comprehensive leak inspection report of high-efficiency filters on the site before installation (it is allowed to include the qualified report after repair), and there must also be a frame-by-frame scanning qualification report after installation (it is allowed to include after repair. compliance report). For places lower than 100 grades, there must be a qualified report for frame scanning and sampling inspection of high-efficiency filters after installation (including repair and plugging) (no less than one tuyere for each room, and when there are many tuyere, the sampling ratio should not be less than 20 %) Guangdong Saite Purification has many years of experience in the decoration and transformation of clean workshops, as well as supporting filtration pharma machinery and cleaning equipment. If necessary, please call to discuss.
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How Mobile Cleanrooms Are Adapting to Changing Environments

Mobile cleanrooms have become an essential part of various industries, including pharmaceuticals, biotechnology, electronics, and aerospace. These versatile units provide a controlled environment for critical operations and have become increasingly important in adapting to changing environments. With the rise of flexible and adaptable solutions, mobile cleanrooms are now more effective than ever in meeting the needs of diverse industries.

Adapting to Industry Needs

Mobile cleanrooms have evolved to meet the specific needs of various industries. In the pharmaceutical and biotechnology sectors, these units are designed to meet stringent cleanliness and safety requirements for the production of medications and medical devices. technology has advanced to support cutting-edge research and development in these industries, allowing for the production of life-saving treatments and technologies. In the electronics sector, mobile cleanrooms have become essential for the production of semiconductors and other sensitive electronic components. The ability to control particulate contamination and environmental factors is crucial for ensuring the quality and reliability of electronic products. Aerospace industries also rely on mobile cleanrooms for the assembly and maintenance of spacecraft, satellites, and other aerospace technologies. These units provide a controlled environment for precision assembly and testing, ensuring the safety and reliability of aerospace hardware.

Mobile cleanrooms are adaptable to the specific requirements of each industry, providing a flexible and cost-effective solution for maintaining controlled environments in rapidly changing industries. As technology and industry standards continue to evolve, mobile cleanrooms will play a crucial role in supporting the changing needs of diverse sectors.

Flexibility and Mobility

One of the key advantages of mobile cleanrooms is their flexibility and mobility. These units can be easily transported to different locations, allowing for on-site operations and rapid deployment in changing environments. This flexibility is particularly valuable in industries where production or research needs may shift frequently, such as in the biotechnology and pharmaceutical sectors. Mobile cleanrooms can be quickly configured to meet specific requirements, providing a tailored solution for various applications. The ability to move these units to different locations also allows for greater efficiency in operations, reducing the need for costly and time-consuming facility modifications.

In addition to their mobility, mobile cleanrooms offer flexibility in terms of their design and configuration. These units can be customized to fit within existing facilities or integrated into larger production environments. This adaptability allows for seamless integration with existing processes and operations, minimizing disruptions and maximizing productivity. As industries continue to evolve and adapt to changing demands, the flexibility and mobility of mobile cleanrooms will play a critical role in supporting their needs.

Advanced Control Systems

Modern mobile cleanrooms are equipped with advanced control systems that allow for precise monitoring and adjustment of environmental parameters. These systems ensure compliance with industry standards and regulatory requirements, providing a controlled environment for critical operations. Temperature, humidity, air quality, and particulate contamination can all be carefully managed within mobile cleanrooms, allowing for high levels of consistency and reliability in production and research processes.

The integration of advanced control systems in mobile cleanrooms also allows for remote monitoring and operation, further enhancing their flexibility and adaptability. Operators can remotely monitor environmental conditions and make real-time adjustments as needed, ensuring that critical operations are carried out under optimal conditions. This level of control is particularly important in industries where strict environmental conditions are required, such as in pharmaceutical manufacturing or semiconductor production.

In addition to environmental control, advanced systems also offer enhanced safety features, such as emergency shut-off and alarm systems. These features provide an added layer of protection for personnel and sensitive pharma machinery, ensuring a safe working environment within mobile cleanrooms. As industries continue to demand higher levels of precision and reliability, the advanced control systems in mobile cleanrooms will be essential in meeting these requirements.

Sustainability and Efficiency

The latest mobile cleanrooms are designed with sustainability and efficiency in mind, offering energy-efficient solutions for maintaining controlled environments. These units are equipped with energy-saving technologies, such as high-efficiency HVAC systems and LED lighting, to minimize their environmental impact. By reducing energy consumption and operating costs, mobile cleanrooms offer a sustainable solution for maintaining critical environments without compromising on performance.

In addition to their energy efficiency, mobile cleanrooms are designed to optimize space and resources, maximizing their productivity and effectiveness. These units are often equipped with modular designs that allow for efficient use of space and easy reconfiguration as needed. This flexibility in layout and design ensures that mobile cleanrooms can adapt to changing production needs, providing a cost-effective solution for industries with dynamic requirements.

The sustainability and efficiency of mobile cleanrooms make them a valuable asset for industries seeking to minimize their environmental footprint and operating costs. As sustainability continues to be a priority for many organizations, the adoption of energy-efficient and resource-conscious solutions such as mobile cleanrooms is expected to grow, driving further innovation and development in this sector.

Future Developments and Applications

Looking ahead, the future of mobile cleanrooms holds exciting possibilities for further innovation and application. Advancements in materials, technologies, and design concepts are expected to result in even more adaptable, efficient, and versatile mobile cleanrooms. The integration of smart technologies, such as IoT sensors and data analytics, will enable real-time monitoring and optimization of mobile pharma clean room operations, further enhancing their effectiveness and reliability.

Beyond their traditional applications, mobile cleanrooms are also expected to find new uses in emerging industries and technologies. The rise of personalized medicine, gene therapy, and advanced biologics is driving demand for flexible and adaptable production environments, making mobile cleanrooms well-suited to support these cutting-edge technologies. Similarly, the growing interest in space exploration and commercial space travel is creating new opportunities for mobile cleanrooms in the assembly and maintenance of spacecraft and related technologies.

In conclusion, mobile cleanrooms are adaptable solutions for changing environments, offering flexibility, mobility, advanced control systems, sustainability, and efficiency. These units have proven to be essential in meeting the specific needs of diverse industries, providing a controlled environment for critical operations and supporting the evolving requirements of rapidly changing sectors. As technology and industry standards continue to evolve, mobile cleanrooms will play a crucial role in adapting to new challenges and opportunities, driving further innovation and development in this important sector.

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