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The greatest threat of pollution in clean rooms comes from the users themselves. In the medical and pharmaceutical industries, the control of microorganisms is very important, especially those that might shed from the skin and deposit in the air flow. Studying the microbial flora in clean rooms is of great significance for microbiologists and quality control personnel to assess the changing trends, especially for the screening of drug-resistant strains and the research on cleaning and disinfection methods.The typical microbial flora in clean rooms is mainly the flora related to human skin, and there may also be microorganisms from other sources, such as the environment and water, but in smaller quantities. Common bacterial genera include Micrococcus, Staphylococcus, Corynebacterium and Bacillus, and fungal genera include Aspergillus and Penicillium. In addition, as the clean room is used for a longer time, some potential pollution factors may gradually accumulate. For example, the aging and wear of equipment may produce fine particles, increasing the pollution risk of the clean room. At the same time, unreasonable operation procedures and poor management may also lead to the occurrence of pollution. For instance, personnel do not strictly follow the entry and exit regulations of the clean room and bring in external contaminants; or the cleaning and disinfection work is not thorough, allowing the remaining microorganisms to multiply and spread.For the pollution control of clean rooms, not only the aspect of microorganisms needs to be concerned, but also the impact of chemical pollution needs to be considered. Some chemical substances may enter the clean room through air transmission, equipment leakage or the introduction of raw materials, posing potential threats to product quality and personnel health. Therefore, establishing a comprehensive pollution monitoring system is crucial, including regular detection of microorganisms, particulate matter and chemical substances, in order to discover problems in time and take effective control measures.In order to further reduce the pollution risk of clean rooms, some additional measures can be taken. For example, strengthen the training of staff, improve their clean awareness and operation norms, and ensure that everyone clearly understands the requirements and precautions of the clean room. At the same time, optimize the maintenance and upkeep plan of equipment, regularly check the sealing and operating status of the equipment, and replace aging or damaged parts in a timely manner. In terms of the selection and management of raw materials, strictly control the quality and avoid introducing raw materials that may carry pollution. In addition, advanced air purification technologies and filtration systems can also be considered to improve the removal efficiency of microorganisms and chemical substances. Through the comprehensive application of these measures, the pollution of clean rooms can be effectively reduced and the safety and stability of the production environment can be ensured.
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Suzhou Pharma Machinery Co.,Ltd.2024/12/23Mia