Tablet clean room design and installation
Tablet clean room design and installation
The production process of tablet dust-free workshop includes granulation, tableting, coating, packaging and other processes. The preparation methods can be summarized as: wet granulation and tableting, dry granulation and tableting, and direct tableting. Granulation, as the processing process of particles, is related to almost all solid preparations. The preparations may...
Text label: tablet dust-free workshop, tablet production workshop design and decoration, tablet production pharmaceutical cleanroom installation
Tablet dust-free pharmaceutical cleanroom design and installation
The production process of tablet dust-free pharmaceutical cleanroom includes granulation, tableting, coating, packaging and other processes. The preparation methods can be summarized as: wet granulation and tableting, dry granulation and tableting, and direct tableting. Granulation is the processing process of particles, which is related to almost all solid preparations. The preparations may be final products or intermediates. The granulation operation makes the particles have a certain corresponding purpose to ensure product quality and smooth production. , the granulation process can be completed in the granulator, the obtained granules should have good fluidity and compressibility, and have suitable mechanical strength, can withstand the damage of loading and unloading and mixing operations, but are pressed in the die When granulating, the granules should be broken; granulation includes wet granulation, dry granulation and spray granulation. During wet granulation, a binder is added to the drug powder, and the powder is agglomerated by the bridging or bonding effect of the binder. The preparation of granules, extrusion granulation, rotary granulation, fluidized granulation and stirring granulation, etc. belong to wet granulation. Because the surface of the granules prepared by wet method is wetted, the surface modification is better, and it has beautiful appearance, It has the advantages of strong wear resistance and good compression formability, and is widely used.
Tabletting is the core operation of tablet production, and its basic equipment is a tablet press, which places various granules or powdery materials in the die holes
, according to different structures, tablet presses can be divided into single punch tablet presses, rotary multi punch tablet presses and high-speed tablet presses. According to different special requirements, there are two-step three-step tablet presses, multi-layer tablet presses Tablet presses and press coaters, etc. The working process of the tablet press can be divided into: the punch part of the lower punch extends into the middle die hole from the lower end of the middle die hole to seal the bottom of the middle die hole; the feeder is used to fill the middle die hole; the punch of the upper punch The head part falls into the middle die hole from the upper end of the middle die hole, and goes down for a certain stroke; the upper punch lifts out of the hole, and the lower punch rises to push the tablet out of the middle die hole to complete a tableting process; the lower punch descends to the original position, ready to next fill. Various tablets have different dosage requirements. Large dosage adjustment is achieved by selecting punches with different punch diameters. In dosage control, the action principle of the feeder also has a considerable impact. For example, physical drugs rely on their own weight and freedom. When rolling into the middle die hole, the filling condition is relatively loose. If multiple forced filling methods are used, the die hole will be filled more and the filling condition will be denser. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for dust-free workshops and dust-free workshops.
Coating is a commonly used preparation process after the tableting process. The surface of the tablet is wrapped with a coating of suitable materials to isolate the tablet from the outside world. According to the different dissolution characteristics of the coating material, it is often divided into sugar-coated tablets. , film-coated tablets, enteric-coated tablets and film-controlled release tablets, etc.; coating methods include roll-on coating method, fluidized bed coating method and compression coating method; coating equipment includes common coating pan, high-efficiency coating The pot type structure of high-efficiency coating machine can be roughly divided into three types: mesh type, gap mesh type and non-porous type. The common coating pan is the most basic and most commonly used tumble coating equipment. This equipment consists of four parts: coating pan, power system, heating system and exhaust system. The work of fluidized bed coating is similar to that of fluidized spray granulation, that is, the coating liquid is sprayed on the surface of the tablet suspended in the air at a certain flow rate, and the heated air volatilizes the solvent on the surface of the tablet to form a film.
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