What aspects are related to the strength of the tablet press

Compression strength is a difficulty often encountered during tablet compression, which will affect tablet compression and coating. The key to loose tablets is closely related to the quality of granules and the operation of the tablet press. Pellet quality is the key to good tablet compression, therefore, the granulation process is critical for tablet quality. The factors affecting the quality of granules mainly include the following aspects: First, the influence of the ingredients of Chinese herbal medicines. For example, some Chinese herbal medicines contain a lot of fiber components. Due to the large elasticity and low viscosity of these medicinal materials, the particles are loose and the film strength is low. In this regard, in actual operation, appropriate solvents and methods can be used to extract and concentrate the active ingredients in such medicinal materials, and then make granules to reduce the elasticity of granules and improve compressibility, thereby increasing the sheet strength; For medicinal materials with a large amount of oil, tableting can easily lead to loose tablets. If these oils are active ingredients, an appropriate amount of adsorbent (such as calcium carbonate) should be added to remove the oil when granulating. If these oils are ineffective ingredients, pressing method or Other degreasing methods degrease, reduce the amount of oil in the particles, improve their cohesive force, and then increase the strength of the film. The second is the impact of fragmentation of Chinese herbal medicines. If the fine powder of Chinese herbal medicines is not fine enough, the cohesiveness of the granules made will be weak, which will easily make the flakes loose. Therefore, the powder must have a certain particle size, which is the prerequisite for making good granules and pressing tablets. The third is the influence of adhesives and wetting agents. Binders and wetting agents play an important role in granulation, and the selection of their types and dosage are directly related to the quality of granules. The choice of binder and wetting agent should be determined according to the characteristics of the powder. If it is a whole raw powder tablet, a high-viscosity binder should be used. Alcohol with a concentration of more than 80% must be used as a wetting agent. If the amount of binder is too small, there will be too much fine powder, resulting in loose flakes. The fourth is the influence of moisture in the particles. The moisture of the granules has a great influence on the flake shape. An appropriate amount of water can increase the plastic deformation of the brittle granules and reduce the elasticity, which is beneficial to tablet compression. The dried granules have high elasticity and low plasticity, making it difficult to be compressed into tablets. If the water content is too high, it will also make the tablet soft, even sticky or block the silo, which will affect the tablet compression. Therefore, the water content of each Chinese medicine tablet must be kept in an appropriate range. In addition, if the tablet is loose due to insufficient pressure during the operation of the tablet press, too fast operation speed of the tablet press, and uneven length of the punch needle, the pressure can be appropriately increased or the speed slowed down, and the punch needle can be replaced. If the pressure is sufficient and the loose tablet still occurs, attention should be paid to other reasons, and do not apply pressure to prevent damage to the tablet press.