Joint trial operation and debugging of clean clean room modular workshop system

The joint trial operation and commissioning of the ventilation and air-conditioning engineering system without production load should be carried out after the single-unit trial operation of the refrigeration equipment and ventilation and air-conditioning equipment has passed. Load combined operation test adjustment...
Text label: clean clean room modular system, joint commissioning and commissioning, sterile plant system

Combined trial operation and commissioning of clean room plant system


The joint trial operation and commissioning of the ventilation and air-conditioning engineering system without production load should be carried out after the single-unit trial operation of the refrigeration equipment and ventilation and air-conditioning equipment has passed. The load combined operation test is adjusted to check whether the temperature, humidity, airflow speed and air cleanliness of the air-conditioning system of the air-conditioning system can meet the design requirements; the normal combined trial operation of the air-conditioning system with cold and heat sources should not be less than 8H, when the completion of the project is completed. When there is a big difference between the season and the design conditions, only the test run without the cold and heat source is carried out, and the continuous test run of the ventilation and dust removal system is not less than 2H. The clean room commissioning personnel, together with the design, construction and construction units, conduct on-site acceptance of the installed system, and check the construction and design that do not meet the requirements and the manufacturing quality of equipment and components, especially where the quality of processing and installation is unqualified, it is necessary to Find out the reasons and understand the modified design documents, and draw the actual system sketches accordingly. For processing and installation, the defect list should be listed item by item, and the construction unit should be corrected in time before the test.


Prepare the instruments and necessary tools required for the test adjustment, check whether the problems in the defect list have been eliminated; whether the power supply, water source, cold and heat source, etc. are ready, the ventilation fan, water pump and various air treatment equipment are ready. Whether the single unit is running normally, and after checking that there is no problem, the test operation can be carried out according to the predetermined plan. After the electrical equipment and its main circuit are checked and determined to be qualified, the air-conditioning equipment should be tested, including the test operation of fans and water pumps, air treatment equipment such as water spray chambers, surface coolers, air heaters and heat exchangers, automatic Clean the oil filter, etc. for inspection, check the installation quality of the equipment through the trial operation, and eliminate the fault in time. This work should be carried out in cooperation with the construction department and the operation department of the construction unit. After the test operation of the air-conditioning equipment, first measure the performance of the ventilator, and then measure and adjust the air volume of the supply and return air system, so that the total air volume, fresh air volume, primary and secondary return air volume of the system, as well as the air volume of each branch air duct, and the supply and return air volume meet the design. It is required to adjust the air volume of each return air outlet in the room to maintain a certain positive pressure. After the air volume of the system is adjusted to meet the design requirements, conditions are created for the determination of the performance of the air conditioner, and the individual tests and adjustments of air treatment equipment such as water spray chambers, surface coolers, air heaters and air filters can be carried out. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean rooms and sterile workshops.














On the basis of item-by-item debugging, a long-term test operation is finally carried out, so that all links of the air-conditioning and automatic adjustment system are put into work to evaluate the comprehensive effect of the system and determine the possible maintenance in the constant temperature room. The allowable fluctuation range of temperature and relative humidity and the stability of air parameters; the measurement and estimation of the cooling capacity of the air-conditioning refrigeration unit can also be carried out at the same time as the performance measurement of the air-conditioning unit. It is a ring buckle, and some can be interspersed to do.
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Layout and construction of ointment production purification pharmaceutical cleanroom

The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and paste making machine, etc.; soft...
Text label: ointment production purification pharmaceutical cleanroom, purification workshop layout construction

Layout and construction of ointment production and purification pharmaceutical cleanroom


The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and ointment machine, etc.; ointment has strict requirements on the hose used for filling, hose material and ointment base No physical and chemical effects, no back suction after extrusion, the inner wall of the tube should be clean, the tube wall should be airtight, the outer wall of the tube can be easily painted with brightly colored patterns and trademarks, and it is not easy to fall off; the commonly used hoses are Coated aluminum pipes, plastic pipes and composite pipes on the inner wall.


The ointment base needs to be fully heated, kept warm and stirred during the preparation process to ensure complete melting of the base. It needs to use a batching tank. The stirring system consists of a motor, a reducer, a stirrer, etc.; the jacket of the batching tank is It can be heated by hot water or steam. When using hot water for heating, according to the principle of convection, the drain valve is installed at the upper part, the water inlet valve is installed at the bottom of the equipment, and the air release valve is installed at the high position of the jacket to prevent the top gas from causing damage. Reduce the heat transfer effect; the stirrer shaft passes through the sealing ring installed at the lid of the pot, in addition to maintaining the vacuum or pressure in the sealed tank, the sealing ring can also prevent the lubricating oil of the transmission system from being polluted, which is convenient for the in and out of the material in the pot; use a vacuum When discharging, the nozzle extends into the bottom of the equipment, and vacuum feeding is used to prevent the volatilization of raw materials; due to the high viscosity of the paste, the inner wall of the batching tank needs to be smooth, and the stirring paddle is framed, and the shape is as close to the inner wall as possible. Generally, for high-viscosity substrates or ointments with high solid content, in order to make the stirring quality high, a circulating pump is often used to carry the material to the outside of the pot to circulate, so as to help the material to turn up and down in the tank and achieve the purpose of stirring evenly. The commonly used colloid conveying pump and stainless steel gear pump. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and sterile workshops.














There are requirements for solid particle size in external ointment. In order to make the ointment base and the drug mix evenly and delicately, and apply on the skin or mucous membrane without irritation, usually after the ingredients are added, the drug needs to be further ground, crushed and mixed evenly. The types of equipment used here are stone mill, ball mill, three-roll mill, colloid mill, emulsifier, etc.
, among which colloid mill is more advanced; colloid mill is composed of upper and lower grinders, with a mill that can precisely control the distance between grinding surfaces, mainly composed of rotor and stator; The gap flows through, depending on the high-speed relative rotation of the two cone surfaces, so that the paste will generate vortex and high-frequency vibration under the action of great friction, shear force and centrifugal force, so that the paste will be crushed and play a very good role. Mixing, homogenizing and emulsification. In the preparation process of ointment, the paste making machine is the key equipment in the configuration process. All materials need to be uniformly stirred, heated and emulsified by the paste making machine. Therefore, the mixer is required to have good performance, convenient operation and easy cleaning. Delicate, smooth and consistent quality ointment.
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Filling and sealing in GMP pharmaceutical cleanroom

Decompression filling varies with the type of eye drop bottle and the size of the production volume. The intermittent pressure reduction filling device arranges the cleaned and sterilized empty eye drop bottles upside down in a flat tray, and put them in In the vacuum filler, the droplets are quantitatively put into the tray from the liquid storage bottle by the pipeline, and the door of the filler is closed...
Text label: GMP pharmaceutical cleanroom, filling and sealing, Zhongjing Global Purification

GMP pharmaceutical cleanroom plant filling and sealing


Decompression filling varies with the type of eye drop bottle and the size of the production volume. The intermittent pressure reduction filling device arranges the cleaned and sterilized empty eye drop bottles upside down in a flat tray, and put them in In the vacuum filling device, the droplets are quantitatively put into the tray from the liquid storage bottle by the pipeline, the door of the filling device is closed, and the pressure is reduced by the vacuum pump. The bottle device is filled with air, restored to normal pressure, poured into the bottle, taken out of the plate, immediately sealed and tightened the cover; a pressure cooker can be used to make a pressure-reduced filling device for small-scale production. Manual filling is suitable for small-scale production in the hospital preparation room. The filling device is mainly composed of two single-stage pistons in series.


A small amount of eye drops is prepared in the preparation room, the prepared eye drops can be put into the infusion bottle, the cap is sterilized, a disposable infusion filter is installed, and an interceptor and a terminal filter are put on; the device is cheap The filtration effect is reliable. The particle count of the filtrate filtered by the terminal filter is much lower than that of the filtrate filtered by the vertical melting glass funnel. This infusion set is one-time use, saving the process of processing various filters. powerful. The fully automatic filling unit integrates machinery, electronics and pneumatics. The production line consists of automatic bottle unscrambler, drum bottle washing machine, ozone sterilization oven, buffer bottle supply disc, filling machine, light inspection machine, It is composed of vertical labeling machine, which has the functions of bottle filling, no bottle filling, inner stopper on the bottle, and outer cover of the bottle with inner stopper. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and purification plants.














The plastic eye drop bottle that needs to be sealed in the GMP workshop can be sealed by hot-melt method, and the eye drop bottle is separated by cellophane. The temperature is about 90-100℃ during ironing, and it can be melted with a little pressure; corneal trauma and Eye drops packaged in ampoules for eye surgery can be filled by hand, sealed by hand, or mechanically sealed; there are top seals and pull seals. , according to the number of flames, it is divided into single flame and double flame, the latter is fast and easy to operate.
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1. Tablet debris The situation where the tablet splits is called splitting. If the split position occurs at the top (or bottom) of the tablet, it is generally called capping. This is a common way to spin off. Uneven pressure distribution and the resulting difference in elastic recovery rate are important causes of gaps. The key to dealing with the debris problem is to use auxiliary materials with low elasticity and high ductility to reduce the overall elastic recovery rate of the material. In addition, too much fine powder in the granules, too dry granules, weak cohesion or insufficient dosage, too thick tablets and too fast inhibition can also cause splitting. 2. Loose tablet The tablet is not hard enough and will crack when slightly touched, which is called loose tablet. 3. During the operation of the tablet press, the surface of the sticky punched tablet is stuck to the chromatography or a small part by the puncher, resulting in a rough, uneven or sunken surface. Typically, this is sticky. If the edge of the tablet is rough or has voids, it can be called stick mold. The main reasons for sticking or sticking are: the particles are not dry enough or the material is not easy to absorb water, the lubricant is not selected correctly or the amount is insufficient, the surface of the punch is rusted or the lettering is rough and not smooth. The reason should be determined and dealt with according to the actual situation. 4. The difference in tablet weight exceeds the limit, indicating that the weight of the tablet exceeds the allowable range of the difference in tablet weight stipulated in the Pharmacopoeia. The reasons and solutions are: (1) The circulation of the granules is not good. Sometimes the number of granules flowing into the die hole is small, resulting in a large difference in the net weight of the tablet. It should be granulated again, or a better flow aid, such as fine powder silica gel, should be added. , to improve the fluidity of particles. (2) There are too many fine powders in the particles or the size of the particles is very different, resulting in heavy and light materials flowing into the die holes. Excess fine powder should be removed or re-granulated; (3) The particles in the silo are generally too small, which will cause fluctuations in the weight of the feed and make the difference in tablet weight beyond the limit. Therefore, the particles in the silo should always exceed 1/3. (4) The consistency of the punch and the die hole is not good. For example, there is a large amount of powder leakage between the periphery of the lower punch and the wall of the die hole, which will cause the 'squeaky punch' condition of the lower punch, which will inevitably lead to insufficient material filling. Therefore, the punch should replace the head die ring.

Air conditioning solutions for clean rooms have come a long way since their inception, evolving to meet the increasingly stringent requirements of modern industries. From pharmaceutical manufacturing to semiconductor production, the demand for clean room environments has continued to grow, leading to innovations in air conditioning technology. In this article, we will explore the evolution of air conditioning solutions for clean rooms, tracking their development from the early days to the present.

The Early Days of Air Conditioning Solutions

In the early days of air conditioning solutions for clean rooms, the focus was primarily on controlling temperature and humidity. Clean rooms were primarily used in industries such as pharmaceuticals and electronics manufacturing, where maintaining precise environmental conditions was crucial to the quality of the final product. Early air conditioning solutions relied on basic HVAC systems to regulate temperature and humidity, but they lacked the sophisticated filtering and monitoring capabilities that are standard in modern clean room environments.

As the demand for clean room technology grew, so did the need for more advanced air conditioning solutions. This led to the development of specialized clean room HVAC systems that were designed to meet the unique requirements of clean room environments. These systems incorporated high-efficiency particulate air (HEPA) filters and other advanced filtration technologies to ensure that the air inside the clean room was free from contaminants. Additionally, these systems often included sophisticated monitoring and control systems to maintain precise environmental conditions.

The Rise of Modular Clean Room HVAC Systems

In recent years, there has been a growing trend towards the use of modular clean room HVAC systems. These systems are designed to be easily installed and reconfigured, allowing for greater flexibility in clean room design and construction. Modular clean room HVAC systems often incorporate advanced filtration technologies and are designed to provide the precise environmental control required in clean room environments. Additionally, these systems are often equipped with advanced monitoring and control systems, allowing for real-time monitoring of environmental conditions and rapid response to any deviations.

One of the key advantages of modular clean room HVAC systems is their ability to be easily expanded or reconfigured to meet changing clean room requirements. This flexibility makes them an ideal choice for industries where clean room requirements may change frequently, such as pharmaceutical manufacturing or research and development facilities. Additionally, modular clean room HVAC systems are often more energy-efficient than traditional HVAC systems, making them a cost-effective choice for clean room environments.

Advanced Monitoring and Control Systems

In addition to advanced filtration technologies, modern air conditioning solutions for clean rooms often incorporate sophisticated monitoring and control systems. These systems are designed to provide real-time monitoring of environmental conditions, allowing for rapid response to any deviations from the desired setpoints. Additionally, advanced monitoring and control systems often include features such as remote access and data logging, allowing for comprehensive documentation of environmental conditions over time.

The use of advanced monitoring and control systems in clean room air conditioning solutions is crucial for maintaining the integrity of the clean room environment. By providing real-time monitoring and rapid response to any deviations, these systems help to ensure that the clean room remains in compliance with industry standards and regulatory requirements. Additionally, the data logging capabilities of these systems provide valuable documentation of environmental conditions, which can be crucial for quality control and regulatory compliance.

Integration of Smart Technologies

Another recent trend in air conditioning solutions for clean rooms is the integration of smart technologies. Smart technologies, such as Internet of Things (IoT) devices and automation systems, are being increasingly used to enhance the capabilities of clean room air conditioning systems. These technologies allow for greater automation of environmental control processes, as well as enhanced remote monitoring and control capabilities.

The integration of smart technologies into clean room air conditioning solutions is expected to have a significant impact on the industry. By providing greater automation and remote monitoring capabilities, these technologies have the potential to increase the efficiency and reliability of clean room environmental control systems. Additionally, the use of smart technologies can help to reduce the risk of human error and provide valuable data for process optimization and quality control.

The Future of Air Conditioning Solutions for Clean Rooms

Looking ahead, the future of air conditioning solutions for clean rooms is likely to be shaped by continued advancements in filtration, monitoring, and control technologies. The demand for clean room environments is expected to continue to grow, driven by the increasing requirements for product quality and regulatory compliance in industries such as pharmaceuticals and electronics manufacturing. As a result, we can expect to see further innovations in clean room air conditioning solutions, with a focus on greater efficiency, flexibility, and reliability.

In conclusion, the evolution of air conditioning solutions for clean rooms has been driven by the increasing demands of modern industries for precise environmental control. From the early days of basic HVAC systems to the current use of advanced filtration, monitoring, and smart technologies, clean room air conditioning solutions have evolved to meet the unique requirements of clean room environments. Looking ahead, we can expect further advancements in the field, as the demand for clean room technology continues to grow.